• Disease: tick-borne encephalitis
  • Viral disease due to Falvivirus infection
  • Species: for example dogs, cats and horses
  • One of the most important tick-borne diseases in human medicine
  • Mainly transmitted by Ixodes ricinus ticks in Germany
  • In human medicine, defined high-risk areas
  • No specific antiviral drug available
  • Direct detection methods
    • PCR
  • Indirect detection methods are not available in routine diagnostics
    • Virus neutralization test (golden standard)
    • IgG-ELISA (positive about 4 weeks post infection)
    • IgM-ELISA (positive about 2 weeks post infection)
  • Fever and neurological signs as the most prominent clinical signs
  • Subclinical to peracute-lethal

Amounts of positive tested animals at LABOKLIN (Bad Kissingen, Germany)

Species

Timeframe

PCR

IgM/IgG ELISA

Dog

2010-2020

1%

5.0%

Cat

2010-2019

0%

0%

Horse

2010-2021

0%

31.0%

Seasonal distribution of dogs tested positive for tick-borne encephalitis (TBE) by direct (PCR) and indirect (IgG-/IgM-ELISA) tests (2010-2020, %)

The seasonal distribution is consistent with the activity pattern of the vector in Germany.